https://ogma.newcastle.edu.au/vital/access/ /manager/Index en-au 5 Optimization of ultrasound-assisted extraction of Helicteres hirsuta Lour. for enhanced total phenolic compound and antioxidant yield https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:33964 Helicteres hirsuta Lour. (H. hirsuta), which has been used as a traditional medicine for malaria and diabetes treatment. Results showed that either ultrasonic temperature or sample-to-solvent ratio had a greater influence on extraction efficiency of total phenolics, flavonoids and antioxidant capacity than that of methanol concentration. Optimal extraction conditions were determined to be ultrasonic temperature of 60 °C, ultrasonic time of 25 min, ultrasonic power of 150W, sample-to-solvent ratio of 3:100 g/mL, and a solvent composition of 40% (v/v) aqueous methanol. Under these conditions, 15.97 mg GAE/g of phenolics, 16.42 mg CE/g of flavonoids, and 13.34 g/100 g of extractable solids were obtained. The highest values for DPPH, ABTS and FRAP assays were also obtained under these conditions, with the exception of CUPRAC (88% maximum value). These optimal extraction conditions can be applied to prepare powdered crude extract for further isolation and purification of individual bioactive compounds for potential use in the pharmaceutical industry.]]> Wed 09 Feb 2022 15:54:39 AEDT ]]> Novel piperazine-1,2,3-triazole leads for the potential treatment of pancreatic cancer https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:54455 Tue 27 Feb 2024 13:53:27 AEDT ]]>